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Inhibition of Protein Synthesis by RA-VII

✍ Scribed by B.V. Sirdeshpande; P.L. Toogood

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 476 KB
Volume: 23
Category: Article
ISSN: 0045-2068
DOI: 10.1006/bioo.1995.1032

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✦ Synopsis

The antitumor natural product RA-VII has been evaluated as an inhibitor of protein synthesis in vitro. Complete inhibition of protein synthesis in rabbit reticulocyte lysates is observed with (5 \mu \mathrm{m}) RA-VII. Mechanistic studies using purified elongation factors and ribosomes identify RA-VII as a peptidyltransferase inhibitor. Thus. similar to the related natural products bouvardin and RA-XII, RA-VII appears to function by binding to eukaryotic ribosomes. 1945 Academic Press. Inc.

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