## Abstract __SELEX was used to create an RNA aptamer targeted to protein tyrosine phosphatase 1B (PTP1B), an enzyme implicated in type 2 diabetes, breast cancer and obesity. We found an aptamer that strongly inhibits PTP1B in vitro with a__ K__~i~ of less than 600 pM. This slowβbinding, highβaffin
β¦ LIBER β¦
Inhibition of an activated Ras protein with genetically selected peptide aptamers
β Scribed by Stephen E. Kurtz; Kim Esposito; Weimin Tang; Rolf Menzel
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 221 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0006-3592
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