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Inhibition of proliferation and CD25 down-regulation by retinoic acid in human adult T cell leukemia cells

✍ Scribed by Miyatake, J-I; Maeda, Y


Book ID
110053449
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
242 KB
Volume
11
Category
Article
ISSN
0887-6924

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CD28 and CTLA-4 are opposing regulators of T cell activation, triggered by the two ligands CD80 and CD86. How these ligands promote either T cell activation via CD28 or inhibition via CTLA-4 is not understood. Using CD80 and CD86 molecules expressed on transfected cells, we have identified a major d