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Inhibition of P-Glycoprotein by Newer Antidepressants

✍ Scribed by Weiss, J.


Book ID
121785660
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2003
Tongue
English
Weight
211 KB
Volume
305
Category
Article
ISSN
0022-3565

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The dopamine theory of depression was studied by assessing the effect of antidepressant drugs on uptake of dopamine, noradrenaline, and serotonin in synaptosomes from rat brain. Five newer drugs--butriptyline, maprotiline, trimipramine, iprindole, and mianserine--exhibited rather potent inhibition o