Influence of P-glycoprotein inhibition o
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Thomas B. Ejsing; Kristian Linnet
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Article
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2005
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John Wiley and Sons
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English
β 77 KB
The distribution of the antidepressant drug nortriptyline (NT) and its main metabolite E-10-hydroxy-nortriptyline (E-10-OH-NT) across the blood-brain barrier was considered in relation to inhibition of the multidrug transporter P-glycoprotein (P-gp). Rats received NT in doses of 25 mg/kg orally, 10