Pharmacokinetics of P-glycoprotein inhib
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Stina SyvΓ€nen; Andrew Hooker; Obaidur Rahman; Helena Wilking; Gunnar Blomquist;
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Article
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2008
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John Wiley and Sons
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English
β 338 KB
This article describes the experimental set-up and pharmacokinetic modeling of P-glycoprotein function in the rat blood-brain barrier using [ 11 C]verapamil as the substrate and cyclosporin A as an inhibitor of P-gp. [ 11 C]verapamil was administered to rats as an i.v. bolus dose followed by graded