𝔖 Bobbio Scriptorium
✦   LIBER   ✦

P.4.004 P-glycoprotein inhibition enhances transport of the antidepressant imipramine across the blood-brain barrier

✍ Scribed by F.E. O'Brien; G. Clarke; P. Fitzgerald; T.G. Dinan; B.T. Griffin; J.F. Cryan


Book ID
118598890
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
68 KB
Volume
22
Category
Article
ISSN
0924-977X

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Pharmacokinetics of P-glycoprotein inhib
✍ Stina SyvΓ€nen; Andrew Hooker; Obaidur Rahman; Helena Wilking; Gunnar Blomquist; πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 338 KB

This article describes the experimental set-up and pharmacokinetic modeling of P-glycoprotein function in the rat blood-brain barrier using [ 11 C]verapamil as the substrate and cyclosporin A as an inhibitor of P-gp. [ 11 C]verapamil was administered to rats as an i.v. bolus dose followed by graded

Influence of P-glycoprotein inhibition o
✍ Thomas B. Ejsing; Kristian Linnet πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 77 KB

The distribution of the antidepressant drug nortriptyline (NT) and its main metabolite E-10-hydroxy-nortriptyline (E-10-OH-NT) across the blood-brain barrier was considered in relation to inhibition of the multidrug transporter P-glycoprotein (P-gp). Rats received NT in doses of 25 mg/kg orally, 10