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Inhibition of matrix metalloproteinase-9 activity improves coronary outcome in an animal model of Kawasaki disease

✍ Scribed by A. C. Lau; T. T. Duong; S. Ito; G. J. Wilson; R. S. M. Yeung


Book ID
108701046
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
434 KB
Volume
157
Category
Article
ISSN
0009-9104

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## Abstract ## Objective Kawasaki disease (KD) is a multisystem vasculitis leading to damage in the coronary circulation and aneurysm formation. Because cardiac tissue from affected children is not available, investigation of the mechanisms responsible for coronary artery damage in KD requires use

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We examined the potential role of the extra-cellular matrix-degrading enzyme, matrix metalloproteinase-9 (MMP-9), in the pathogenesis of cerebral amyloid angiopathy (CAA)-induced spontaneous hemorrhage. The amyloid-beta peptide (Abeta) induced the synthesis, release and activation of MMP-9 in murine