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Inhibition of interleukin-1β converting enzyme by N-acyl-aspartyl aryloxymethyl ketones

✍ Scribed by Adnan M.M. Mjalli; Justin J. Zhao; Kevin T. Chapman; Nancy A. Thornberry; Erin P. Peterson; Malcolm MacCoss; William K. Hagmann

Book ID
108038853
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
271 KB
Volume
5
Category
Article
ISSN
0960-894X

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Inhibition of interleukin-1β converting
Inhibition of interleukin-1β converting enzyme by N-Acyl-aspartic acid ketones
✍ Adnan M.M. Mjalli; Kevin T. Chapman; Justin J. Zhao; Nancy A. Thornberry; Erin P 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 190 KB

N-Acyl aspartic acid ketones (3a-3n) were prepared from the corresponding bromomethyl ketone. The inhibition of interleukin-lJ3 converting enzyme (ICE) by these single amino acid ketones is reported. The best compound had Ki of 3.5 I~M versus ICE. Peptidyl aldehydes and ketones have been demonstrat