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Cleavage of Actin by Interleukin 1β -Converting Enzyme to Reverse DNase I Inhibition

✍ Scribed by Celik Kayalar, Tõnis Örd, M. Pia Testa, Li-Tao Zhong and Dale E. Bredesen


Book ID
123639512
Publisher
National Academy of Sciences
Year
1996
Tongue
English
Weight
1005 KB
Volume
93
Category
Article
ISSN
0027-8424

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N-Acyl aspartic acid ketones (3a-3n) were prepared from the corresponding bromomethyl ketone. The inhibition of interleukin-lJ3 converting enzyme (ICE) by these single amino acid ketones is reported. The best compound had Ki of 3.5 I~M versus ICE. Peptidyl aldehydes and ketones have been demonstrat