Inhibition of interleukin-1β converting
✍
Adnan M.M. Mjalli; Kevin T. Chapman; Justin J. Zhao; Nancy A. Thornberry; Erin P
📂
Article
📅
1995
🏛
Elsevier Science
🌐
English
⚖ 190 KB
N-Acyl aspartic acid ketones (3a-3n) were prepared from the corresponding bromomethyl ketone. The inhibition of interleukin-lJ3 converting enzyme (ICE) by these single amino acid ketones is reported. The best compound had Ki of 3.5 I~M versus ICE. Peptidyl aldehydes and ketones have been demonstrat