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Inhibition of Indoleamine 2,3-Dioxygenase does not Impede Oral Tolerance

✍ Scribed by Bowman, C.C.; DeVito, M.J.; Ross, D.G.; Selgrade, M.J.K.

Book ID
119277332
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
163 KB
Volume
117
Category
Article
ISSN
1097-6825

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Induction of indoleamine 2,3-dioxygenase (IDO) by IFN-+ results in growth inhibition of Toxoplasma and Chlamydia spp. as well as tumor cells. This is caused by the degradation, and therefore depletion, of L-tryptophan necessary for cell protein synthesis. Human macrophages stimulated with IFN-+ expr