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Inhibition of IL-6-induced STAT3 activation in myeloma cells by protein kinase a

✍ Scribed by Lun Song; yan Li; Bei-fen Shen


Book ID
107466573
Publisher
Chinese Anti-Cancer Association
Year
2001
Tongue
English
Weight
399 KB
Volume
13
Category
Article
ISSN
1000-9604

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A small molecule, LLL12 inhibits constit
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## Abstract We characterized the effects of a newly developed signal transducers and activators of transcription 3 (STAT3) inhibitor, LLL12 in multiple myeloma (MM) cells. LLL12 specifically inhibited STAT3 phosphorylation, nuclear localization, DNA binding activity, down‐regulated STAT3 downstream