A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells

A small molecule, LLL12 inhibits constit

A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells

✍ Li Lin; Don M. Benson Jr.; Stephanie DeAngelis; Courtney E. Bakan; Pui-Kai Li; C 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 891 KB

## Abstract We characterized the effects of a newly developed signal transducers and activators of transcription 3 (STAT3) inhibitor, LLL12 in multiple myeloma (MM) cells. LLL12 specifically inhibited STAT3 phosphorylation, nuclear localization, DNA binding activity, down‐regulated STAT3 downstream