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Inhibition of IGF II-induced redistribution of mannose 6-phosphate receptors by the phosphatidylinositol 3-kinase inhibitor, wortmannin

✍ Scribed by Christian Körner; Thomas Braulke


Book ID
116122787
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
532 KB
Volume
118
Category
Article
ISSN
0303-7207

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The ability of acute insulin treatment to elicit a redistribution of the liver insulin-like growth factor-II/ mannose 6-phosphate (IGF-II/M6P) receptor has been studied in rats, using cell fractionation. Injection of insulin (0.4 -50 g) led to a time-and dose-dependent decrease in IGF-II binding act