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Inhibition of Human Acetyl- and Butyrylcholinesterase by Novel Carbamates of (−)- and (+)-Tetrahydrofurobenzofuran and Methanobenzodioxepine

✍ Scribed by Luo, Weiming; Yu, Qian-sheng; Kulkarni, Santosh S.; Parrish, Damon A.; Holloway, Harold W.; Tweedie, David; Shafferman, Avigdor; Lahiri, Debomoy K.; Brossi, Arnold; Greig, Nigel H.


Book ID
120938635
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
504 KB
Volume
49
Category
Article
ISSN
0022-2623

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Human brain acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were sequentially extracted, first with a Tris-saline buffer (S,) and then with 1% (wlv) Triton X-100 (S,). About 20 and 30% of the AChE and BuChE activities were recovered in S, and most of the remaining enzymes in S,. Main m