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Carbamates with Differential Mechanism of Inhibition Toward Acetylcholinesterase and Butyrylcholinesterase

✍ Scribed by Darvesh, Sultan; Darvesh, Katherine V.; McDonald, Robert S.; Mataija, Diane; Walsh, Ryan; Mothana, Sam; Lockridge, Oksana; Martin, Earl


Book ID
111938499
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
714 KB
Volume
51
Category
Article
ISSN
0022-2623

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## Abstract We have reported that benzene‐1,2‐, 1,3‐, and 1,4‐di‐__N__‐substituted carbamates (**1–15**) are characterized as the conformationally constrained inhibitors of acetylcholinesterase and mimic __gauche__, __eclipsed__, and __anti__‐conformations of acetylcholine, respectively (__J Bioche