Inhibition of Human Blood Acetylcholinesterase and Butyrylcholinesterase by Some Alkaloids
β Scribed by L. P. Kuznetsova; E. B. Nikol'skaya; E. E. Sochilina; M. D. Faddeeva
- Book ID
- 110338073
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 79 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0022-0930
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Oximes are enzyme reactivators used in treating poisoning with organophosphorus cholinesterase (AChE) inhibitors. The oxime dose which can be safely administered is limited by the intrinsic toxicity of the substances such as their own AChE-inhibiting tendency. Clinical experience with the available
## Abstract We have reported that benzeneβ1,2β, 1,3β, and 1,4βdiβ__N__βsubstituted carbamates (**1β15**) are characterized as the conformationally constrained inhibitors of acetylcholinesterase and mimic __gauche__, __eclipsed__, and __anti__βconformations of acetylcholine, respectively (__J Bioche