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Inhibition of HPV-16 E7 oncogenic activity by HPV-16 E2

✍ Scribed by Gammoh, N; Isaacson, E; Tomaić, V; Jackson, D J; Doorbar, J; Banks, L


Book ID
109972290
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
228 KB
Volume
28
Category
Article
ISSN
0950-9232

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## Abstract ## Background Human papillomavirus type 16 (HPV16) E7 is an unstable oncoprotein with low immunogenicity. In previous work, we prepared the E7GGG gene containing point mutations resulting in substitution of three amino acids in the pRb‐binding site of the HPV16 E7 protein. ## Methods