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Inhibition of HIV-1 Reverse Transcriptase by Aryl-Substituted Naphto- and Anthraquinones

✍ Scribed by T. V. Ilina; E. A. Semenova; T. R. Pronyaeva; A. G. Pokrovskii; I. V. Nechepurenko; E. E. Shults; O. I. Andreeva; S. N. Kochetkov; G. A. Tolstikov


Book ID
110329199
Publisher
SP MAIK Nauka/Interperiodica
Year
2002
Tongue
English
Weight
32 KB
Volume
382
Category
Article
ISSN
1607-6729

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Various aryl I-pyrryl sulfones were synthesized and tested as inhibitors of HIV-1. 2-Nitrophenyl-2-ethoxycarbonyl-1 -pynyl sulfone, the most active among test derivatives, was selected as lead compound of the aryl pyrryl sulfone series. The in vitru anti-HIV-1 activity and cytotoxicity of 41 compoun