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Structural investigation of HIV-1 nonnucleoside reverse transcriptase inhibitors: 2-Aryl-substituted benzimidazoles

✍ Scribed by Natasza E. Ziółkowska; Christopher J. Michejda; Grzegorz D. Bujacz

Book ID: 108213119
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 560 KB
Volume: 937
Category: Article
ISSN: 0022-2860
DOI: 10.1016/j.molstruc.2009.08.005

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## Abstract TIBO (Tetrahydro‐imidazo[4,5,1‐jk][1,4]‐benzodiazepin‐2‐one) and nevirapine (11‐cyclopropyl‐5,11‐dihydro‐4‐methyl‐6H‐dipyrido[3,2‐b:2′,3′‐e][1,4]diazepin‐6‐one) are models for two classes of nonnucleoside inhibitors of the HIV‐1 virus reverse transcriptase (NNRTI). This work presents th