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Inhibition of Glutamate Uptake with l-trans-Pyrrolidine-2,4-Dicarboxylate Potentiates Glutamate Toxicity in Primary Hippocampal Cultures

✍ Scribed by Michael B. Robinson; Sina Djali; Jeffrey R. Buchhalter

Book ID: 111177986
Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 542 KB
Volume: 61
Category: Article
ISSN: 0022-3042
DOI: 10.1111/j.1471-4159.1993.tb07447.x

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## Abstract An increased concentration of extracellular glutamate is associated with neuronal damage induced by cerebral ischemia. We have demonstrated previously that exposure of cultured cerebellar granule neurons to L‐__trans__‐pyrrolidine‐2,4‐dicarboxylate (PDC), a glutamate uptake inhibitor, i