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Glutamate toxicity in neuron-enriched and neuron–astrocyte co-cultures: effect of the glutamate uptake inhibitor l-trans-pyrrolidine-2,4-dicarboxylate

✍ Scribed by Nabila Amin; Brian Pearce


Book ID
117410184
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
227 KB
Volume
30
Category
Article
ISSN
0197-0186

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Glutamate uptake inhibitor L-trans-pyrro
✍ Octavio García; Lourdes Massieu 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 526 KB

## Abstract An increased concentration of extracellular glutamate is associated with neuronal damage induced by cerebral ischemia. We have demonstrated previously that exposure of cultured cerebellar granule neurons to L‐__trans__‐pyrrolidine‐2,4‐dicarboxylate (PDC), a glutamate uptake inhibitor, i