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Continuous administration of the glutamate uptake inhibitor L-trans-pyrrolidine-2,4-dicarboxylate produces striatal lesion

✍ Scribed by Jean-Charles Liévens; Martin Dutertre; Claude Forni; Pascal Salin; Lydia Kerkerian-Le Goff

Book ID: 117386941
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 814 KB
Volume: 50
Category: Article
ISSN: 0169-328X
DOI: 10.1016/s0169-328x(97)00182-4

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## Abstract An increased concentration of extracellular glutamate is associated with neuronal damage induced by cerebral ischemia. We have demonstrated previously that exposure of cultured cerebellar granule neurons to L‐__trans__‐pyrrolidine‐2,4‐dicarboxylate (PDC), a glutamate uptake inhibitor, i