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Inhibition of Fibrillization and Accumulation of Prefibrillar Oligomers in Mixtures of Human and Mouse α-Synuclein †

✍ Scribed by Rochet, Jean-Christophe; Conway, Kelly A.; Lansbury, Peter T.


Book ID
126849714
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
306 KB
Volume
39
Category
Article
ISSN
0006-2960

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## Abstract Abnormal protein aggregation in the brain is linked to the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Recent studies revealed that the oligomeric form of aggregates is most likely the toxic species, and thus could be a go