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Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds

✍ Scribed by Mario Caruana; Tobias Högen; Johannes Levin; Andreas Hillmer; Armin Giese; Neville Vassallo


Book ID
113622484
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
852 KB
Volume
585
Category
Article
ISSN
0014-5793

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✍ Ilona B. Bruinsma; Kim A. Bruggink; Karsten Kinast; Alexandra A. M. Versleijen; 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 846 KB

## Abstract The fibrillization of α‐synuclein (α‐syn) is a key event in the pathogenesis of α‐synucleinopathies. Mutant α‐syn (A53T, A30P, or E46K), each linked to familial Parkinson's disease, has altered aggregation properties, fibril morphologies, and fibrillization kinetics. Besides α‐syn, Lewy