Inhibition of development of peripheral neuropathy in streptozotocin-induced diabetic rats with N-acetylcysteine
β Scribed by M. Sagara; J. Satoh; R. Wada; S. Yagihashi; K. Takahashi; M. Fukuzawa; G. Muto; Y. Muto; T. Toyota
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 762 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0012-186X
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It has been shown that parameters of oxidative stress are increased in experimental diabetic neuropathy. The glutathione redox system is one of the intracellular scavenger systems for neutralizing free oxygen radicals. In this investigation we studied the effect of glutathione-treatment on the devel
## Abstract The pharmacokinetic parameters of 5βfluorouracil were compared after intravenous administration at a dose of 30 mg/kg to control SpragueβDawley rats and to rats with diabetes mellitus induced by streptozotocin (DMIS). In DMIS rats, the area under the plasma concentrationβtime curve from