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Effects of a fructose-rich diet and the aldose reductase inhibitor, ONO-2235, on the development of diabetic neuropathy in streptozotocin-treated rats

✍ Scribed by N. Hotta; H. Kakuta; H. Fukasawa; M. Kimura; N. Koh; M. Iida; H. Terashima; T. Morimura; N. Sakamoto

Publisher
Springer
Year
1985
Tongue
English
Weight
555 KB
Volume
28
Category
Article
ISSN
0012-186X

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Effect of a new aldose reductase inhibit
Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235) on peripheral nerve disorders in streptozotocin-diabetic rats
✍ R. Kikkawa; I. Hatanaka; H. Yasuda; N. Kobayashi; Y. Shigeta; H. Terashima; T. M πŸ“‚ Article πŸ“… 1983 πŸ› Springer 🌐 English βš– 270 KB

A new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E-methyl-3-phenylpropenylidene]rhodanine (ONO-2235) was administered orally to streptozotocin-diabetic rats (60 mg/kg IV) for 14 days and its effect on motor nerve conduction velocity studied. The compound significantly improved motor nerve