This study describes reduced motor nerve conduction velocity and increased resistance to hypoxia-induced conduction failure in sciatic nerves of rats after four weeks of streptozotocin-induced diabetes (both effects were significant at p < 0.05). These changes occurred in the absence of any deficit
Adenosine triphosphatase in nerves and ganglia of rats with streptozotocin-induced diabetes or galactosaemia; effects of aldose reductase inhibition
โ Scribed by J. E. Lambourne; A. M. Brown; N. Calcutt; D. R. Tomlinson; G. B. Willars
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 599 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0012-186X
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A possible relationship between increased sorbitol concentration and decreased myo-inositol concentration in peripheral nerves of diabetic rats has been examined. To this end, sorbinil, an aldose reductase inhibitor, was used either to prevent or reverse elevation of nerve sorbitol concentration in