TriΒ―uoromethyl ketones 1 and 2, have been prepared from trisnorsqualene aldehyde 3. These compounds and their corresponding alcohols 4 and 7 have been found to be good inhibitors of the biosynthesis of cholesterol in HepG2 cells. The inhibition is correlated with a decrease of the HMG-CoA reductase
β¦ LIBER β¦
Inhibition of cholesterol synthesis by cyclopropylamine derivatives of squalene in human hepatoblastoma cells in culture
β Scribed by W. A. Van Sickle; M. R. Angelastro; P. Wilson; J. R. Cooper; A. Marquart; M. A. Flanagan
- Book ID
- 112774120
- Publisher
- Springer-Verlag
- Year
- 1992
- Tongue
- English
- Weight
- 474 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0024-4201
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