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Influence of trapidil and derivatives on cholesterol synthesis and esterification in cultured cells

✍ Scribed by BEITZ, J; CORSINI, A; BELLOSTA, S; BERNINI, F; FUMAGALLI, R; MEST, H; PAOLETTI, R

Book ID
122925213
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
406 KB
Volume
24
Category
Article
ISSN
1043-6618

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Sterol synthesis in liver in vivo is regulated at the site of the reaction catalyzed by 3-hydroxy-3-methylglutaryl-CoA reductase through a feedback system thought to involve either cholesterol or one or more of the products of its metabolism. Cholesterol feeding results in repression of the synthesi