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Inhibition of cell growth by oxygenated derivatives of cholesterol

✍ Scribed by CHEN, HARRY W.; KANDUTSCH, ANDREW A.; WAYMOUTH, CHARITY


Book ID
109692953
Publisher
Nature Publishing Group
Year
1974
Tongue
English
Weight
558 KB
Volume
251
Category
Article
ISSN
0028-0836

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Sterol synthesis in liver in vivo is regulated at the site of the reaction catalyzed by 3-hydroxy-3-methylglutaryl-CoA reductase through a feedback system thought to involve either cholesterol or one or more of the products of its metabolism. Cholesterol feeding results in repression of the synthesi