Hepatic extraction, metabolism, and bili
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Christian Farabos; Marie-Christine Haaz; Pierre Gires; Jacques Robert
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Article
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2001
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John Wiley and Sons
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English
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Irinotecan (CPT-11) is a semisynthetic derivative of camptothecine that has proved activity in the treatment of colorectal carcinoma. The metabolites identiยฎed in humans include SN-38, SN-38 glucuronide, and several CYP3A-derived metabolites. We have studied the hepatic extraction, metabolism, and b