𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Metabolism of cysteinyl leukotrienes in non-recirculating rat liver perfusion : Hepatocyte heterogeneity in uptake and biliary excretion

✍ Scribed by Matthias WETTSTEIN; Wolfgang GEROK; Dieter HÄUSSINGER

Book ID
115126243
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
917 KB
Volume
181
Category
Article
ISSN
1432-1327

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Hepatic extraction, metabolism, and bili
Hepatic extraction, metabolism, and biliary excretion of irinotecan in the isolated perfused rat liver
✍ Christian Farabos; Marie-Christine Haaz; Pierre Gires; Jacques Robert 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 199 KB 👁 2 views

Irinotecan (CPT-11) is a semisynthetic derivative of camptothecine that has proved activity in the treatment of colorectal carcinoma. The metabolites identi®ed in humans include SN-38, SN-38 glucuronide, and several CYP3A-derived metabolites. We have studied the hepatic extraction, metabolism, and b

Hypoxia and CCI4-induced liver injury, b
Hypoxia and CCI4-induced liver injury, but not acidosis, impair metabolism of cysteinyl leukotrienes in perfused rat liver
✍ Matthias Wettstein; Wolfgang Gerok; Prof. Dr. Dieter Häussinger 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 796 KB

Uptake, metabolism and biliary elimination of infused cysteinyl leukotrienes were investigated in single-pass perfused rat liver. Hypoxia did not impair uptake of infused [3H]leukotriene C4, but inhibited biliary excretion of radioactivity by about 50% compared with normoxic control experiments. In