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Inhibition of benzo[a]pyrene-7,8-diol formation in vitro by complex organic mixtures

✍ Scribed by David A. Dankovic; Berta L. Thomas; Richard C. Zangar; Douglas W. Later; David L. Springer


Book ID
103657062
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
594 KB
Volume
55
Category
Article
ISSN
0300-483X

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## Abstract Treatment of isolated rat liver nuclei with 7Ξ², 8α‐dihydroxy‐9Ξ±, 10α‐epoxy‐7, 8, 9, 10‐tetrahy‐drobenzo[a]pyrene, the ultimate carcinogenic metabolite of benzo[a]pyrene, resulted in inhibition of transcription as measured by radioactive precursor incorporation into RNA. The mechanism of