Inhibition of bacterial and viral sialidases by 3-fluoro-N-acetylneuraminic acid
β Scribed by Teruhiko Hagiwara; Isao Kijima-Suda; Tatsuo Ido; Hiroshi Ohrui; Kenkichi Tomita
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 373 KB
- Volume
- 263
- Category
- Article
- ISSN
- 0008-6215
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π SIMILAR VOLUMES
Thl: perawtylstcd mcthyl cstcr dcrivativcs of 7-rpi-i-NeuSAc (ta), H-epi-NeuSAc (3 a), and 7.8-bis-epi-NcuSAc (4 a) wcrc transformed hy trimcihylsilyl trifluoromethanesulronale into the corrcsponding 2-cieoxy-2,3-didehydro derivatives 2b-4 b. As minor products the 4.5-osazolino derivatives 5 b rind
## Abstract The peracetylated methyl ester 1 of Nβacetylneuraminic acid was transformed into the oxazoline derivative 2, which was hydrogenated with Pd/C/H~2~ to give the 4βdeoxyβNeu5Ac2en derivative 3. Acid cleavage of the oxazoline 2 by trifluoroacetic acid (THF) gave the 4βepiβNeu5Ac2en derivati