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Inhibition of sialidases from viral, bacterial and mammalian sources by analogues of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid modified at the C-4 position

✍ Scribed by Cindy T. Holzer; Mark Itzstein; Betty Jin; Michael S. Pegg; Wendy P. Stewart; Wen-Yang Wu


Publisher
Springer US
Year
1993
Tongue
English
Weight
484 KB
Volume
10
Category
Article
ISSN
1573-4986

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Structural Variations on N-acetylneurami
✍ Schreiner, Erwin ;Zbiral, Erich ;Kleineidam, Reinhard G. ;Schauer, Roland 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 652 KB

## Abstract The peracetylated methyl ester 1 of N‐acetylneuraminic acid was transformed into the oxazoline derivative 2, which was hydrogenated with Pd/C/H~2~ to give the 4‐deoxy‐Neu5Ac2en derivative 3. Acid cleavage of the oxazoline 2 by trifluoroacetic acid (THF) gave the 4‐epi‐Neu5Ac2en derivati