Thl: perawtylstcd mcthyl cstcr dcrivativcs of 7-rpi-i-NeuSAc (ta), H-epi-NeuSAc (3 a), and 7.8-bis-epi-NcuSAc (4 a) wcrc transformed hy trimcihylsilyl trifluoromethanesulronale into the corrcsponding 2-cieoxy-2,3-didehydro derivatives 2b-4 b. As minor products the 4.5-osazolino derivatives 5 b rind
Structural Variations ofN-Acetylneuraminic Acid, 10. Synthesis of 2,7-, 2,8-, and 2,9-Dideoxy- and 2,4,7-Trideoxy-2,3-didehydro-N-acetylneuraminic Acids and Their Behavior Towards Sialidase fromVibrio cholerae
โ Scribed by Zbiral, Erich ;Schreiner, Erwin ;Christian, Rudolf ;Kleineidam, Reinhard G. ;Schauer, Roland
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 763 KB
- Volume
- 1989
- Category
- Article
- ISSN
- 0947-3440
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๐ SIMILAR VOLUMES
## Abstract The methyl ester of __N__โacetylneuraminic acid ฮฒโmethyl ketoside (Neu5Ac1Meโ2ฮฒโMe) (1) is used as common starting material for the synthesis of the title compounds. Combined derivatization reactions with reagents thiophosgene, __p__โcresol, benzoyl chloride, and acetic anhydride/pyridi
## Abstract The peracetylated methyl ester 1 of Nโacetylneuraminic acid was transformed into the oxazoline derivative 2, which was hydrogenated with Pd/C/H~2~ to give the 4โdeoxyโNeu5Ac2en derivative 3. Acid cleavage of the oxazoline 2 by trifluoroacetic acid (THF) gave the 4โepiโNeu5Ac2en derivati