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Inhibition of antigen-induced contraction of guinea-pig airways by a leukotriene synthesis inhibitor, BAY x1005

✍ Scribed by Phillip J. Gardiner; Nigel J. Cuthbert; Hilary P. Francis; Mary F. Fitzgerald; Angela M. Thompson; Tracey G. Carpenter; Umesh P. Patel; Benjamin B. Newton; Klaus Mohrs; Reiner Müller-Peddinghaus; William A. Taylor


Book ID
115889337
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
743 KB
Volume
258
Category
Article
ISSN
0014-2999

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Antigen (ovalbumin)-induced contraction of guinea-pig isolated trachea, which largely resulted from the endogenous release of peptidoleukotrienes, was strongly inhibited by the non-selective phosphodiesterase (PDE) inhibitor theophylline and, more potently, by the selective PDE type IV inhibitors ro