Inhibition of 5-aminolevulinic acid dehydratase activity by gabaculine
✍ Scribed by Pulcherie Kedy; Philippe Bruyant; Alain P. Balangé
- Book ID
- 108365323
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 653 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0031-9422
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An automated assay for the estimation of S-aminolevulinic acid dehydratase activity in human erythrocytes has been devised. The present design allows the performance of thirteen analyses per hour. Samples are hemolysed by saponin in the flow system. Lateral interaction between consecutive samples is
The first intermediate substrate in the heme synthetic pathway, 5-aminolevulinic acid (ALA), is neurotoxic in animal models and may be responsible for some of the adverse neurologic outcomes in lead poisoning and porphyria in adult humans. ALA is a substrate for the enzyme aminolevulinic acid dehydr