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Inhibition by lymphoblastoid interferon of growth of cells derived from the human breast

✍ Scribed by F. Balkwill; D. Watling; J. Taylor-Papadimitriou

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
693 KB
Volume
22
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Human lymphoblastoid interferon inhibited the growth in vitro of fibroblasts and epithelial cells from normal, hyperplastic and neoplastic human breast tissue. At an interferon concentration of 10^3^ international units (IU) per ml, the inhibitory effects on monolayer growth were completely reversible but the growth potential of cells at lower density in colony‐forming cultures was not completely recovered. Studies on the cell cycle distribution of interferon‐treated cells demonstrated that the growth‐inhibitory effect was not due to an effect on one specific phase of the cell cycle, but to a lengthening of all phases.

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