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Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells

✍ Scribed by Kazunori Fukuda; Yuko Hibiya; Michihiro Mutoh; Masatoshi Koshiji; Seigou Akao; Hisayoshi Fujiwara

Book ID
117536826
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
118 KB
Volume
66
Category
Article
ISSN
0378-8741

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Cyclooxygenase-2 (COX-2) over-expression is critically involved in tumor formation. Intracellular pH (pHi) has been shown to be alkaline in cancer cells, and to be an important trigger for cell proliferation. This study therefore analyzed the relationship between pHi and COX-2 expression. HRT-18 and