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Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein

✍ Scribed by Fei Ye; Josephine Wu; Trish Dunn; Jizu Yi; Xiaodi Tong; David Zhang


Book ID
116333136
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
285 KB
Volume
211
Category
Article
ISSN
0304-3835

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## Abstract The overexpression of cyclooxygenase‐2 (COX‐2) and inducible nitric oxide synthase (iNOS) has been previously reported in head and neck squamous cell carcinoma (HNSCC), as well as in many cancers. We hypothesized that endogenous nitric oxide (NO) might increase the expression of COX‐2 i