Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells
β Scribed by Ajay Goel; C.Richard Boland; Dharam P Chauhan
- Book ID
- 117467058
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 441 KB
- Volume
- 172
- Category
- Article
- ISSN
- 0304-3835
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Cyclooxygenase (COX)-2 is one of the rate-limiting enzymes in the conversion of arachidonic acid to prostaglandins and other eicosanoids. Recent studies have shown enhanced expression of COX-2 in cancer cells of several tissues. We investigated the expression of COX-2 and prostaglandin (PG) E 2 prod
Cyclooxygenase-2 (COX-2) over-expression is critically involved in tumor formation. Intracellular pH (pHi) has been shown to be alkaline in cancer cells, and to be an important trigger for cell proliferation. This study therefore analyzed the relationship between pHi and COX-2 expression. HRT-18 and