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Inhibition and Structure of Trichomonas vaginalis Purine Nucleoside Phosphorylase with Picomolar Transition State Analogues †

✍ Scribed by Rinaldo-Matthis, Agnes; Wing, Corin; Ghanem, Mahmoud; Deng, Hua; Wu, Peng; Gupta, Arti; Tyler, Peter C.; Evans, Gary B.; Furneaux, Richard H.; Almo, Steven C.; Wang, Ching C.; Schramm, Vern L.

Book ID
127336077
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
480 KB
Volume
46
Category
Article
ISSN
0006-2960

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✍ Gary B. Evans; Richard H. Furneaux; Graeme J. Gainsford; Vern L. Schramm; Peter 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 314 KB

AbstractÐSyntheses of the `Immucillins', potent aza-C-nucleoside inhibitors of purine nucleoside phosphorylase are reported as well as those of 5-deoxy-, 5-deoxy¯uoro-and 2-deoxy-analogues and others having modi®ed bases.