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Exploring Structure−Activity Relationships of Transition State Analogues of Human Purine Nucleoside Phosphorylase

✍ Scribed by Evans, Gary B.; Furneaux, Richard H.; Lewandowicz, Andrzej; Schramm, Vern L.; Tyler, Peter C.


Book ID
115471266
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
186 KB
Volume
46
Category
Article
ISSN
0022-2623

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Synthesis of Transition State Analogue I
✍ Gary B. Evans; Richard H. Furneaux; Graeme J. Gainsford; Vern L. Schramm; Peter 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 314 KB

AbstractÐSyntheses of the `Immucillins', potent aza-C-nucleoside inhibitors of purine nucleoside phosphorylase are reported as well as those of 5-deoxy-, 5-deoxy¯uoro-and 2-deoxy-analogues and others having modi®ed bases.