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Inhibition and induction of metronidazole and antipyrine metabolism

✍ Scribed by S. Loft; J. Sonne; H. E. Poulsen; K. T. Petersen; B. G. Jørgensen; M. Døssing


Publisher
Springer
Year
1987
Tongue
English
Weight
816 KB
Volume
32
Category
Article
ISSN
0031-6970

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A pharmacokinetic study of metronidazole disposition was performed in 10 patients with severe liver disease, the majority of whom also had impaired renal function. Following a single intravenous dose, systemic clearance of metronidazole was decreased by 66% in patients compared with healthy