Differential induction of antipyrine metabolism by rifampicin
β Scribed by E. -L. Toverud; A. R. Boobis; M. J. Brodie; S. Murray; P. N. Bennett; V. Whitmarsh; D. S. Davies
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 469 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0031-6970
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
pared with intravenous administration. These data Cytochrome P450 (CYP) enzymes, which metabolize clearly indicate that prehepatic metabolism of veranumerous drugs, are expressed both in liver and in expamil (presumably in the gut wall) is preferentially intrahepatic tissues. CYP3A4 for example is p
Bupropion, a novel antidepressant drug, is known to be a moderate hepatic metabolism-inducer in rodents at high doses but not in young human volunteers. Eleven elderly depressed patients (mean age 76.9 \* 8.7 years) entered in the study and received 100 mg of bupropion t.i.d. for 28 days. An antipyr