Using two enzyme-linked immunosorbent assays specific for inhibin A and pro-C inhibin, levels of the two proteins were assessed in maternal serum from 43 Down syndrome and 300 chromosomally normal pregnancies at 15-17 weeks' gestation. Compared to the control pregnancies, both inhibin A and pro-C in
Inhibin A and non-Down syndrome aneuploidy
β Scribed by H. S. Cuckle; I. K. Sehmi; R. G. Jones
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 114 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0197-3851
No coin nor oath required. For personal study only.
β¦ Synopsis
a High risk=sampled prior to invasive prenatal diagnosis. b Indication for invasive prenatal diagnosis: history=previous pregnancy with Edwards' syndrome; screening=positive maternal serum screening test. c With hydrops. d With cystic hygroma.
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Initial studies of immunoreactive inhibin using a commercial assay have shown levels to be increased in three second-trimester series of maternal samples from Down's syndrome-affected pregnancies. This assay detected non-specifically all forms of circulating inhibin, dimeric and free alpha subunits,
In second-trimester Down syndrome pregnancies, levels of inhibin-A (the alpha-betaA dimer) in maternal serum and amniotic fluid (AF) are significantly higher and lower than in normal pregnancy, respectively. Since AF also contains inhibin-B (the alpha-betaB dimer) and precursor inhibins, we have exa
The value of measuring inhibin-A (asA dimer) with human chorionic gonadotrophin (total or the sub-units free a-hCG and free P-hCG separately), alpha-fetoprotein (AFP), and unconjugated oestriol (uE,) was examined to determine the effect on the performance of serum screening for Down's syndrome betwe
Abnormal number of chromosomes, aneuploidy, is the most common abnormality in leukemia and cancer. However, the casual relationship between aneuploidy and cancer is unclear. Additional copies of chromosome 21 are frequently found in leukemic cells. Constitutional trisomy 21 that characterizes Down S
Case-control studies in the Caucasian population showed that maternal serum inhibin-A is elevated in Down syndrome pregnancies and may be a useful second-trimester marker in addition to human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP). Data in the Asian population are lacking. We meas