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Perspective: chromosomal aneuploidy in leukemia—lessons from down syndrome

✍ Scribed by Shai Izraeli

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
87 KB
Volume
24
Category
Article
ISSN
0278-0232

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✦ Synopsis

Abnormal number of chromosomes, aneuploidy, is the most common abnormality in leukemia and cancer. However, the casual relationship between aneuploidy and cancer is unclear. Additional copies of chromosome 21 are frequently found in leukemic cells. Constitutional trisomy 21 that characterizes Down Syndrome is associated with markedly increased risk for childhood leukemia. In this perspective I review recent studies that suggest that constitutional trisomy 21 promotes leukemic transformation during fetal hematopoiesis. As most of childhood leukemias arise in-utero, these studies are of general relevance to sporadic childhood leukemias.

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