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Inhibin A and pro-αC inhibin in Down syndrome and normal pregnancies

✍ Scribed by Donato D'Antona; Euan M. Wallace; Catherine Shearing; J. Peter Ashby; Nigel P. Groome

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
141 KB
Volume
18
Category
Article
ISSN
0197-3851

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✦ Synopsis

Using two enzyme-linked immunosorbent assays specific for inhibin A and pro-C inhibin, levels of the two proteins were assessed in maternal serum from 43 Down syndrome and 300 chromosomally normal pregnancies at 15-17 weeks' gestation. Compared to the control pregnancies, both inhibin A and pro-C inhibin were significantly elevated in the Down syndrome pregnancies with median levels, expressed as multiples of the normal median, of 1•53 MoM and 1•34 MoM, respectively (P<0•001 and P=0•046 compared to controls). Levels of inhibin A and pro-C inhibin were weakly but significantly correlated in both the control and the Down syndrome sera (r=0•25, P<0•0001; r=0•4, P=0•008, respectively). These data suggest that the mechanism(s) underlying the elevated inhibin levels observed in Down syndrome may affect the regulation of both the inhibin -and A -subunits.

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